Gamma Delta Tocotrienols Reduce Hepatic Triglyceride Synthesis and VLDL Secretion
نویسندگان
چکیده
منابع مشابه
Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion.
AIM Present study aimed to elucidate the suppression of serum lipids by gamma- and delta-tocotrienol (γδT3). METHODS The lipid-lowering effects of γδT3 were investigated using HepG2 liver cell line, hypercholesterolemic mice and borderline-high cholesterol patients. RESULTS In-vitro results demonstrated two modes of action. First, γδT3 suppressed the upstream regulators of lipid homeostasis...
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RATIONALE Dysregulation of hepatic triglyceride (TG)-rich very low-density lipoproteins (VLDL-TG) in obesity and type 2 diabetes contributes to the dyslipidemia that leads to cardiovascular morbidity. The central nervous system (CNS), particularly the hypothalamus, regulates hepatic lipid metabolism. Although the underlying neurocircuitry remains elusive, glycine has been documented to enhance ...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2010
ISSN: 1880-3873,1340-3478
DOI: 10.5551/jat.4911